Anti-Cytokeratin 13抗体[AE8] (ab16112)

概述

  • 产品名称Anti-Cytokeratin 13抗体[AE8]
    参阅全部 Cytokeratin 13 一抗
  • 描述
    小鼠单克隆抗体[AE8] to Cytokeratin 13
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rabbit, Human
  • 免疫原

    Rabbit esophageal keratins.

  • 常规说明


    This antibody is specific for Cytokeratin 13, which is a marker for oesophageal type differentiation which is expressed by various internal stratified epithelia.

性能

应用

Our Abpromise guarantee covers the use of ab16112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 25076852
WB 1/1000 - 1/3000. Predicted molecular weight: 50 kDa.
IHC-P Use at an assay dependent concentration.

靶标

  • 组织特异性Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
  • 疾病相关Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰O-glycosylated; glycans consist of single N-acetylglucosamine residues.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 47 kDa cytokeratin antibody
    • CK-13 antibody
    • CK13 antibody
    • Cytokeratin 13 antibody
    • Cytokeratin-13 antibody
    • K13 antibody
    • K1C13_HUMAN antibody
    • Ka13 antibody
    • Keratin 13 antibody
    • Keratin antibody
    • keratin type I cytoskeletal 13 antibody
    • Keratin-13 antibody
    • Krt-1.13 antibody
    • Krt1-13 antibody
    • KRT13 antibody
    • MGC161462 antibody
    • MGC3781 antibody
    • type I cytoskeletal 13 antibody
    • Type I keratin Ka13 antibody
    • WSN2 antibody
    see all

Anti-Cytokeratin 13 antibody [AE8] 图像

  • ab16112 staining Cytokeratin 13 in Human pharynx tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and antigen retrieval was by heat mediation in Tris pH9. Samples were incubated with primary antibody (undiluted) for 1 hour at 20°C. An undiluted HRP-conjugated Goat anti-mouse IgG polyclonal was used as the secondary antibody.

    See Abreview

Anti-Cytokeratin 13 antibody [AE8] (ab16112)参考文献

This product has been referenced in:
  • Okuda Y  et al. Wnt signaling as a possible promoting factor of cell differentiation in pleomorphic adenomas. Int J Med Sci 11:971-8 (2014). ICC/IF ; Human . Read more (PubMed: 25076852) »
  • Rival-Gervier S  et al. Kinetics and epigenetics of retroviral silencing in mouse embryonic stem cells defined by deletion of the D4Z4 element. Mol Ther 21:1536-50 (2013). Read more (PubMed: 23752310) »

See all 10 Publications for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Tris pH9
Sample Human Tissue sections (pharynx)
Specification pharynx
Permeabilization No
Fixative Formaldehyde
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提交于 Oct 29 2013

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