Anti-Cytokeratin 10抗体[DE-K10] (ab80523)


  • 产品名称Anti-Cytokeratin 10抗体[DE-K10]
    参阅全部 Cytokeratin 10 一抗
  • 描述
    小鼠单克隆抗体[DE-K10] to Cytokeratin 10
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Cat, Dog, Human
  • 免疫原

    Cytoskeletal preparation extracted from Human ectocervical epithelium.

  • 阳性对照
    • A431 cells. Skin.



Our Abpromise guarantee covers the use of ab80523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明ICC/IF: Use at an assay dependent dilution.
    IHC-P: Use at a concentration of 0.5 - 1 µg/ml. Antigen retrieval is not required.
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 组织特异性Seen in all suprabasal cell layers including stratum corneum.
    • 疾病相关Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
      Defects in KRT10 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
    • 序列相似性Belongs to the intermediate filament family.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BCIE antibody
      • BIE antibody
      • CK 10 antibody
      • CK-10 antibody
      • Cytokeratin-10 antibody
      • EHK antibody
      • K10 antibody
      • K1C10_HUMAN antibody
      • Keratin 10 antibody
      • Keratin antibody
      • Keratin type i cytoskeletal 10 antibody
      • Keratin type I cytoskeletal 59 kDa antibody
      • Keratin-10 antibody
      • Keratin10 antibody
      • KPP antibody
      • KRT10 antibody
      • type I cytoskeletal 10 antibody
      see all

    Anti-Cytokeratin 10 antibody [DE-K10] 图像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human skin tissue using 1µg/ml ab80519 in with a peroxidase-conjugated secondary antibody and an AEC chromogen. Note cytoplasmic staining of epidermal region.
    • Anti-Cytokeratin 10 antibody [DE-K10] (ab80523) at 2 µg/ml + A431 cell lysate

      Predicted band size : 60 kDa
      Observed band size : 60 kDa

    Anti-Cytokeratin 10 antibody [DE-K10] (ab80523)参考文献

    ab80523 has not yet been referenced specifically in any publications.

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