Anti-Cytochrome P450 Reductase抗体(ab106255)

概述

  • 产品名称Anti-Cytochrome P450 Reductase抗体
    参阅全部 Cytochrome P450 Reductase 一抗
  • 描述
    山羊多克隆抗体to Cytochrome P450 Reductase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Rabbit, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Chinese Hamster
  • 免疫原

    Synthetic peptide:

    C-TNPPRTNVLYE

    , corresponding to internal sequence amino acids 381-391 of Human Cytochrome P450 Reductase (NP_000932.3).

  • 阳性对照
    • Human, Mouse and Rat Liver lysates.

性能

应用

Our Abpromise guarantee covers the use of ab106255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 77 kDa).

靶标

  • 功能This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
  • 疾病相关Defects in POR are the cause of adrenal hyperplasia variant type (AHV) [MIM:201750]; also known as Antley-Bixler syndrome-like phenotype with disordered steroidogenesis. AHV is a rare variant of congenital adrenal hyperplasia. It is an autosomal recessive disorder with apparent combined P450C17 and P450C21 deficiency. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can also present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
    Defects in POR are a cause of isolated disordered steroidogenesis (IDS) [MIM:201750].
  • 序列相似性In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
    Contains 1 flavodoxin-like domain.
  • 细胞定位Endoplasmic reticulum membrane. Anchored to the ER membrane by its N-terminal hydrophobic region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CPR antibody
    • CYPOR antibody
    • DKFZp686G04235 antibody
    • FLJ26468 antibody
    • NADPH Cytochrome P450 Reductase antibody
    • NADPH dependent cytochrome P450 reductase antibody
    • NADPH--cytochrome P450 reductase antibody
    • NCPR_HUMAN antibody
    • P450 (cytochrome) oxidoreductase antibody
    • P450 Cytochrome Oxidoreductase antibody
    • P450R antibody
    • por antibody
    see all

Anti-Cytochrome P450 Reductase antibody 图像

  • Anti-Cytochrome P450 Reductase antibody (ab106255) at 0.1 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 77 kDa

Anti-Cytochrome P450 Reductase antibody (ab106255)参考文献

ab106255 has not yet been referenced specifically in any publications.

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