概述
- 产品名称Anti-Cytochrome P450 2D6抗体
参阅全部 Cytochrome P450 2D6 一抗 - 描述兔多克隆抗体to Cytochrome P450 2D6
- 经测试应用适用于: WBmore details
- 种属反应性与反应: Human
预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
- 免疫原
Synthetic peptide corresponding to a region within internal amino acids 431-480 (EAFLPFSAGR RACLGEPLAR MELFLFFTSL LQHFSFSVPT GQPRPSHHGV) of Human Cytochrome P450 2D6 (NP_000097).
- 阳性对照
- OVCAR3 cell lysate
性能
- 形式Liquid
- 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- 存储溶液Preservative: None
Constituents: 2% Sucrose, PBS -
Concentration information loading... - 纯度Immunogen affinity purified
- 克隆多克隆
- 同种型IgG
- 研究领域
相关产品
- Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab98137 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T. |
靶标
- 相关性Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
- 细胞定位Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
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数据库链接
- Entrez Gene: 1565 Human
- Entrez Gene: 171522 Rat
- Omim: 124030 Human
- SwissProt: P10635 Human
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别名
- CPD6 antibody
- CYP2D antibody
- CYP2D6 antibody
see all
Anti-Cytochrome P450 2D6 antibody 图像
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Western blot - Cytochrome P450 2D6 antibody (ab98137)Anti-Cytochrome P450 2D6 antibody (ab98137) at 1 µg/ml (in 5% skim milk / PBS buffer) + OVCAR3 cell lysate at 10 µg
Predicted band size : 56 kDa
Anti-Cytochrome P450 2D6 antibody (ab98137)参考文献
ab98137 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"