Anti-Cyp26B1抗体(ab113640)
Key features and details
- Goat polyclonal to Cyp26B1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Cyp26B1抗体
参阅全部 Cyp26B1 一抗 -
描述
山羊多克隆抗体to Cyp26B1 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Dog -
免疫原
Synthetic peptide corresponding to Human Cyp26B1 aa 400-500 (internal sequence).
Database link: P450 26B -
阳性对照
- Human spleen and small intestine (submucosal plexus) tissues; Human testis
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab113640于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
Use a concentration of 3.75 µg/ml.
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说明 |
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IHC-P
Use a concentration of 3.75 µg/ml. |
靶标
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功能
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. -
组织特异性
Highly expressed in brain, particularly in the cerebellum and pons. -
疾病相关
Radiohumeral fusions with other skeletal and craniofacial anomalies -
序列相似性
Belongs to the cytochrome P450 family. -
细胞定位
Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 56603 Human
- Entrez Gene: 232174 Mouse
- Entrez Gene: 312495 Rat
- Omim: 605207 Human
- SwissProt: Q9NR63 Human
- SwissProt: Q811W2 Mouse
- SwissProt: G3V7X8 Rat
- Unigene: 91546 Human
see all -
别名
- CP26 antibody
- CP26B_HUMAN antibody
- CYP26A2 antibody
see all
图片
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ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human small intestine (submucosal plexus) tissue by Immunohistochemistry.
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ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.
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ab113640, at 3.75 µg/ml, staining Cyp26B1 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.
数据表及文件
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Datasheet download
文献 (0)
ab113640 尚未被引用在任何文献中。