Anti-Cytochrome P450 26B抗体(ab113236)

概述

  • 产品名称Anti-Cytochrome P450 26B抗体
    参阅全部 Cytochrome P450 26B 一抗
  • 描述
    兔多克隆抗体to Cytochrome P450 26B
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant Human Cytochrome P450 26B.

  • 阳性对照
    • Human Adrenal gland and Human brain, cerebellum tissues; HepG2 whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab113236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
  • 组织特异性Highly expressed in brain, particularly in the cerebellum and pons.
  • 疾病相关Radiohumeral fusions with other skeletal and craniofacial anomalies
  • 序列相似性Belongs to the cytochrome P450 family.
  • 细胞定位Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CP26 antibody
    • CP26B_HUMAN antibody
    • CYP26A2 antibody
    • cyp26b1 antibody
    • Cytochrome P450 26A2 antibody
    • Cytochrome P450 26B1 antibody
    • Cytochrome P450 family 26 subfamily B polypeptide 1 antibody
    • Cytochrome P450 retinoic acid-inactivating 2 antibody
    • Cytochrome P450 retinoid metabolizing protein antibody
    • Cytochrome P450 subfamily XXVIA, polypeptide 2 antibody
    • Cytochrome P450 subfamily XXVIB polypeptide 1 antibody
    • Cytochrome P450RAI-2 antibody
    • DKFZp686G0638 antibody
    • dol antibody
    • EC 1.14. antibody
    • fc21d03 antibody
    • MGC129613 antibody
    • P450 26A2 antibody
    • P450 retinoic acid inactivating 2 antibody
    • P450RAI 2 antibody
    • P450RAI2 antibody
    • Retinoic acid metabolizing cytochrome antibody
    • Retinoic acid-metabolizing cytochrome antibody
    • RHFCA antibody
    • stocksteif antibody
    • wu:fc21d03 antibody
    • wu:fc26h10 antibody
    • zgc:76999 antibody
    see all

Anti-Cytochrome P450 26B antibody 图像

  • ab113236, at 10µg/ml, staining Cytochrome P450 26B in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.
  • ab113236, at 10µg/ml, staining Cytochrome P450 26B in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.
  • Anti-Cytochrome P450 26B antibody (ab113236) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 58 kDa

Anti-Cytochrome P450 26B antibody (ab113236)参考文献

ab113236 has not yet been referenced specifically in any publications.

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