Anti-Cytochrome P450 17A1抗体(ab125876)

概述

• 产品名称
  Anti-Cytochrome P450 17A1抗体
  参阅全部 Cytochrome P450 17A1 一抗
• 描述
  兔多克隆抗体to Cytochrome P450 17A1
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Monkey
• 免疫原

  Recombinant fragment, corresponding to amino acids 13 - 326 of Human Cytochrome P450 17A1 (P05093).

• 阳性对照
  • MCF-7 cell lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  pH: 7.00
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cytochromes

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cancer
  • Growth factors
  • Hormones

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipases

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Cytochromes

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • MCF7 whole cell lysate (ab3871)

应用

靶标

• 功能
  Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
• 通路
  Lipid metabolism; steroid biosynthesis.
• 疾病相关
  Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).
• 序列相似性
  Belongs to the cytochrome P450 family.
• 翻译后修饰
  Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
• 细胞定位
  Membrane.

• Target information above from: UniProt accession P05093 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 1586 Human
  • Omim: 609300 Human
  • SwissProt: P05093 Human
  • Unigene: 438016 Human
• 别名
  • 20 lyase antibody
  • CP17A_HUMAN antibody
  • CPT7 antibody

  • CYP17 antibody
  • CYP17A1 antibody
  • CYPXVII antibody
  • Cytochrome P450 17A1 antibody
  • Cytochrome P450 family 17 antibody
  • Cytochrome P450 family 17 subfamily A polypeptide 1 antibody
  • Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia antibody
  • Cytochrome p450 XVIIA1 antibody
  • Cytochrome P450-C17 antibody
  • Cytochrome P450c17 antibody
  • OTTHUMP00000020382 antibody
  • P450 C17 antibody
  • P450c17 antibody
  • S17AH antibody
  • Steroid 17 alpha hydroxylase/17,20 lyase antibody
  • Steroid 17 alpha monooxygenase antibody
  • Steroid 17-alpha-hydroxylase/17 antibody
  • Steroid 17-alpha-monooxygenase antibody

  see all

实验方案

• Western blot protocols