重组Anti-COX6B1抗体[EPR7646] (ab137089)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7646] to COX6B1
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-COX6B1抗体[EPR7646]
参阅全部 COX6B1 一抗 -
描述
兔单克隆抗体[EPR7646] to COX6B1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF or IHC-P -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide within Human COX6B1 aa 1-100. The exact sequence is proprietary.
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阳性对照
- HepG2 and Caco 2 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20ºC. -
存储溶液
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
EPR7646 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab137089于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 10 kDa.
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说明 |
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WB
1/1000 - 1/10000. Predicted molecular weight: 10 kDa. |
靶标
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功能
Connects the two COX monomers into the physiological dimeric form. -
疾病相关
Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. -
序列相似性
Belongs to the cytochrome c oxidase subunit 6B family. -
细胞定位
Mitochondrion intermembrane space. - Information by UniProt
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数据库链接
- Entrez Gene: 1340 Human
- Entrez Gene: 110323 Mouse
- Entrez Gene: 502592 Rat
- Omim: 124089 Human
- SwissProt: P14854 Human
- SwissProt: P56391 Mouse
- SwissProt: P80430 Rat
- Unigene: 431668 Human
see all -
别名
- COX 6B antibody
- COX VIb 1 antibody
- COX VIb-1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab137089 被引用在 1 文献中.
- Kim SE et al. Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction. Age (Dordr) 37:9787 (2015). PubMed: 25929654