Anti-Cytochrome C抗体(ab28967)

概述

  • 产品名称Anti-Cytochrome C抗体
    参阅全部 Cytochrome C 一抗
  • 描述
    鸡多克隆抗体to Cytochrome C
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Cow, Human
  • 免疫原

    Full length native protein (purified) (Cow)

  • 阳性对照
    • Rat PC12 cell lysate

应用

Our Abpromise guarantee covers the use of ab28967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/2000 - 1/10000.
WB 1/2000 - 1/10000. Detects a band of approximately 12 kDa (predicted molecular weight: 12 kDa).

靶标

  • 功能Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • 疾病相关Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • 序列相似性Belongs to the cytochrome c family.
  • 翻译后修饰Binds 1 heme group per subunit.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

Anti-Cytochrome C antibody 图像

  • Anti-Cytochrome C antibody (ab28967) + Rat PC12 cell lysate at 30 µg

    Predicted band size : 12 kDa
    Observed band size : 12 kDa

Anti-Cytochrome C antibody (ab28967)参考文献

ab28967 has not yet been referenced specifically in any publications.

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