概述

  • 产品名称Anti-Cytochrome C抗体
    参阅全部 Cytochrome C 一抗
  • 描述
    兔多克隆抗体to Cytochrome C
  • 特异性This antibody detects the 15 kDa cytochrome C.
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Chicken
  • 免疫原

    Synthetic peptide corresponding to residues surrounding amino acid 70 of rat Cytochrome C. (Peptide available as ab38265.)

  • 阳性对照
    • Jurkat cell lysate, NIH3T3 cell lysate and rat kidney tissue lysate.

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应用

Our Abpromise guarantee covers the use of ab18738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 12 kDa.Can be blocked with Cytochrome C peptide (ab38265).
IP Use a concentration of 10 - 20 µg/ml.

靶标

  • 功能Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
    Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
  • 疾病相关Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
  • 序列相似性Belongs to the cytochrome c family.
  • 翻译后修饰Binds 1 heme group per subunit.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CYC antibody
    • CYC_HUMAN antibody
    • CYCS antibody
    • Cytochrome c antibody
    • Cytochrome c somatic antibody
    • HCS antibody
    • THC4 antibody
    see all

Anti-Cytochrome C antibody 图像



  • Predicted band size : 12 kDa

    Western Blot analysis of Left Lane: Jurkat cell lysate and Right Lane: 3T3 cell lysates labeling Cytochrome C with ab18738.

Anti-Cytochrome C antibody (ab18738)参考文献

This product has been referenced in:
  • Dutta S  et al. The steroid hormone environment during primordial follicle formation in perinatal mouse ovaries. Biol Reprod 91:68 (2014). Mouse . Read more (PubMed: 25078683) »
  • Vucetic M  et al. Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1a and AMPKa. Biochim Biophys Acta 1810:1252-61 (2011). Read more (PubMed: 21945600) »

See all 5 Publications for this product

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Thank you for your enquiry. I'm happy to report that the immunogen shares 100% homology with the sequence in chicken. I hope this information helps. Please do not hesitate to contact us if you need anything further.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"