功能Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
疾病相关Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:250790]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.
序列相似性Belongs to the cytochrome b5 family. Contains 1 cytochrome b5 heme-binding domain.
细胞定位Cytoplasm and Endoplasmic reticulum membrane. Microsome membrane.