概述

  • 产品名称
    Cytochalasin B
  • 描述
    Cell permeable actin polymerization抑制剂. Reversible KV1.5 blocker.
  • 生物学描述
    Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker (IC50 = 4 μM). Inhibits I(Kur). Cytochalasin A (ab143481) analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo.
  • 纯度
    > 97%

性能

  • 化学名称
    (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
  • 分子量
    479.61
  • 化学结构
    Chemical Structure
  • 分子式
    C29H37NO5
  • CAS编号
    14930-96-2
  • PubChem识别号
    5311281
  • 存放说明
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO to 10 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@@H]1CCC[C@@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)Cc4ccccc4)C)O)O
  • 来源

    Drechslera dematoidea

  • 研究领域

文献

This product has been referenced in:
  • Giambelluca MS  et al. Characterization of the Na/HCO3(-) Cotransport in Human Neutrophils. Cell Physiol Biochem 33:982-90 (2014). Read more (PubMed: 24714077) »
  • Choi BH  et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol 289:C425-36 (2005). Read more (PubMed: 15800051) »
  • Bousquet PF  et al. Effects of cytochalasin B in culture and in vivo on murine Madison 109 lung carcinoma and on B16 melanoma. Cancer Res 50:1431-9 (1990). Read more (PubMed: 2302708) »
  • MacLean-Fletcher S & Pollard TD Mechanism of action of cytochalasin B on actin. Cell 20:329-41 (1980). Read more (PubMed: 6893016) »

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