概述

  • 产品名称Anti-CysLT2抗体
    参阅全部 CysLT2 一抗
  • 描述
    兔多克隆抗体to CysLT2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the 1st extracellular domain of Human CysLT2.

  • 阳性对照
    • Human Heart tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
  • 组织特异性Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLTR2_HUMAN antibody
    • CYSLT2 antibody
    • CYSLT2R antibody
    • CYSLTR 2 antibody
    • CysLTR2 antibody
    • Cysteinyl leukotriene CysLT2 receptor antibody
    • Cysteinyl leukotriene receptor 2 antibody
    • G protein coupled receptor antibody
    • G protein coupled receptor GPCR21 antibody
    • G protein coupled receptor HG57 antibody
    • G-protein coupled receptor GPCR21 antibody
    • G-protein coupled receptor HG57 antibody
    • GPCR antibody
    • HG57 antibody
    • hGPCR21 antibody
    • HPN321 antibody
    • PSEC0146 antibody
    see all

Anti-CysLT2 antibody 图像

  • ab115453, at 10 µg/ml, staining CysLT2 in formalin-fixed, paraffin-embedded Human Heart tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CysLT2 antibody (ab115453)参考文献

This product has been referenced in:
  • Shirasaki H  et al. Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa. Allergol Int 62:223-8 (2013). IHC ; Human . Read more (PubMed: 23524649) »

See 1 Publication for this product

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
Sample Mouse Cell (mouse/human retinal cross-sections)
Specification mouse/human retinal cross-sections
Permeabilization No
Fixative Paraformaldehyde
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提交于 Jan 13 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"