概述

  • 产品名称
  • 描述
    兔多克隆抗体to CysLT2
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the 1st extracellular domain of Human CysLT2.

  • 阳性对照
    • Human Heart tissue

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
  • 组织特异性
    Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
  • 序列相似性
    Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CLTR2_HUMAN antibody
    • CYSLT2 antibody
    • CYSLT2R antibody
    • CYSLTR 2 antibody
    • CysLTR2 antibody
    • Cysteinyl leukotriene CysLT2 receptor antibody
    • Cysteinyl leukotriene receptor 2 antibody
    • G protein coupled receptor antibody
    • G protein coupled receptor GPCR21 antibody
    • G protein coupled receptor HG57 antibody
    • G-protein coupled receptor GPCR21 antibody
    • G-protein coupled receptor HG57 antibody
    • GPCR antibody
    • HG57 antibody
    • hGPCR21 antibody
    • HPN321 antibody
    • PSEC0146 antibody
    see all

Anti-CysLT2 antibody 图像

  • ab115453, at 10 µg/ml, staining CysLT2 in formalin-fixed, paraffin-embedded Human Heart tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CysLT2 antibody (ab115453)参考文献

This product has been referenced in:
  • Shirasaki H  et al. Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa. Allergol Int 62:223-8 (2013). IHC ; Human . Read more (PubMed: 23524649) »

See 1 Publication for this product

Product Wall

Application
Immunocytochemistry/ Immunofluorescence
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C
Sample
Mouse Cell (mouse/human retinal cross-sections)
Specification
mouse/human retinal cross-sections
Permeabilization
No
Fixative
Paraformaldehyde
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提交于 Jan 13 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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