概述

性能

应用

Our Abpromise guarantee covers the use of ab19043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 6 µg/ml.
WB Use at an assay dependent dilution. PubMed: 19729835

靶标

  • 组织特异性Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
  • 通路Lipid metabolism; bile acid biosynthesis.
  • 疾病相关Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
  • 序列相似性Belongs to the cytochrome P450 family.
  • 细胞定位Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 25 hydroxycholesterol 7 alpha hydroxylase antibody
    • 25-hydroxycholesterol 7-alpha-hydroxylase antibody
    • CP7B antibody
    • CP7B1_HUMAN antibody
    • Cyp7b1 antibody
    • Cytochrome P450 7B1 antibody
    • Cytochrome P450 family 7 subfamily B polypeptide 1 antibody
    • Cytochrome P450 subfamily VIIB polypeptide 1 antibody
    • Oxysterol 7-alpha-hydroxylase antibody
    • Oxysterol 7alpha hydroxylase antibody
    see all

Anti-CYP7B1 antibody 图像

  • ab19043 at 4µg/ml, staining CYP7B1 in Human Breast tissue sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Image shows textured cytoplasm staining in ductal epithelial cells. Steamed antigen retrieval with pH 6 citrate buffer was performed, and HRP-staining was used.

Anti-CYP7B1 antibody (ab19043)参考文献

This product has been referenced in:
  • Leuenberger N  et al. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest : (2009). WB ; Mouse . Read more (PubMed: 19729835) »

See 1 Publication for this product

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