Anti-CYP4V2抗体(ab90271)

概述

• 产品名称
  Anti-CYP4V2抗体
  参阅全部 CYP4V2 一抗
• 描述
  兔多克隆抗体to CYP4V2
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
• 免疫原

  Synthetic peptide from a region within internal sequence amino acids 432-481 (YFPNPEEFQP ERFFPENAQG RHPYAYVPFS AGPRNCIGQK FAVMEEKTIL) of Human CYP4V2 (NP_997235)

• 阳性对照
  • Jurkat cell lysate

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cytochromes

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipases

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Cytochromes

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Jurkat membrane extract lysate (ab30130)

应用

靶标

• 功能
  Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye.
• 组织特异性
  Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.
• 疾病相关
  Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
• 序列相似性
  Belongs to the cytochrome P450 family.
• 细胞定位
  Endoplasmic reticulum membrane.

• Target information above from: UniProt accession Q6ZWL3 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 285440 Human
  • Entrez Gene: 102294 Mouse
  • Entrez Gene: 266761 Rat
  • Omim: 608614 Human
  • SwissProt: Q6ZWL3 Human
  • SwissProt: Q9DBW0 Mouse
  • SwissProt: A2RRT9 Rat
  • Unigene: 587231 Human

  • Unigene: 245297 Mouse
  • Unigene: 201722 Rat

  see all
• 别名
  • BCD antibody
  • CP4V2_HUMAN antibody
  • CYP4AH1 antibody

  • CYP4V 2 antibody
  • CYP4V2 antibody
  • Cytochrome P450 4V2 antibody
  • Cytochrome P450, family 4, subfamily V, polypeptide 2 antibody
  • Retina CYP4V2 antibody

  see all

实验方案

• Western blot protocols