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功能
Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye.
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组织特异性
Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.
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疾病相关
Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
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序列相似性
Belongs to the cytochrome P450 family.
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细胞定位
Endoplasmic reticulum membrane.
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Information by UniProt
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数据库链接
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别名
- BCD antibody
- CP4V2_HUMAN antibody
- CYP4AH1 antibody
- CYP4V 2 antibody
- CYP4V2 antibody
- Cytochrome P450 4V2 antibody
- Cytochrome P450, family 4, subfamily V, polypeptide 2 antibody
- Retina CYP4V2 antibody
see all