Anti-CYP46A1抗体(ab198889)
Key features and details
- Rabbit polyclonal to CYP46A1
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CYP46A1抗体
参阅全部 CYP46A1 一抗 -
描述
兔多克隆抗体to CYP46A1 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to Human CYP46A1 (internal sequence). Gene Accession: NP_006659.
Database link: Q9Y6A2 -
阳性对照
- Human lymphoma tissue lysate and Human brain tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab198889于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/25 - 1/100.
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WB |
1/200 - 1/1000. Predicted molecular weight: 57 kDa.
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说明 |
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IHC-P
1/25 - 1/100. |
WB
1/200 - 1/1000. Predicted molecular weight: 57 kDa. |
靶标
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相关性
The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain. Cyp46 is also known as 24S-cholesterol hydroxylase -
细胞定位
Endoplasmic reticulum -
数据库链接
- Entrez Gene: 10858 Human
- Entrez Gene: 13116 Mouse
- Omim: 604087 Human
- SwissProt: Q9Y6A2 Human
- SwissProt: Q9WVK8 Mouse
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别名
- Cholesterol 24-hydroxylase antibody
- CP46 antibody
- CYP46 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab198889 被引用在 1 文献中.
- Hutchinson SA et al. Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene 40:2872-2883 (2021). PubMed: 33742124