概述

  • 产品名称Anti-CYP2R1抗体
    参阅全部 CYP2R1 一抗
  • 描述
    兔多克隆抗体to CYP2R1
  • 经测试应用适用于: IHC-P, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the C terminal region of human CYP2R1.

  • 阳性对照
    • NCI-H460 cell line lysate.

性能

应用

Our Abpromise guarantee covers the use of ab80101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/10 - 1/50.
WB 1/50 - 1/100. Predicted molecular weight: 57 kDa.
ELISA 1/1000.

靶标

  • 功能Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
  • 疾病相关Defects in CYP2R1 are the cause of rickets vitamin D-dependent type 1B (VDDR1B) [MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. A disorder caused by a selective deficiency of the active form of vitamin D (1,25-dihydroxyvitamin D3) and resulting in defective bone mineralization and clinical features of rickets. The patients sera have low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activityand low levels of 25-hydroxyvitamin D.
  • 序列相似性Belongs to the cytochrome P450 family.
  • 细胞定位Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CP2R1_HUMAN antibody
    • CYP2R1 antibody
    • Cytochrome P450 2R1 antibody
    • Cytochrome P450 family 2 R1 antibody
    • Cytochrome P450 family 2 subfamily R polypeptide 1 antibody
    • EC 1.14.13.15 antibody
    • MGC4663 antibody
    • Vitamin D 25 hydroxylase antibody
    • Vitamin D 25-hydroxylase antibody
    see all

Anti-CYP2R1 antibody 图像

  • Anti-CYP2R1 antibody (ab80101) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 57 kDa
    Observed band size : 64 kDa (why is the actual band size different from the predicted?)
  • ab80101 at 1/50 dilution staining CYP2R1 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

Anti-CYP2R1 antibody (ab80101)参考文献

This product has been referenced in:
  • O'Shaughnessy PJ  et al. Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. J Clin Endocrinol Metab 96:2851-60 (2011). WB ; Human . Read more (PubMed: 21715529) »

See 1 Publication for this product

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