Anti-CYP21A2抗体(ab64887)
Key features and details
- Rabbit polyclonal to CYP21A2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CYP21A2抗体
参阅全部 CYP21A2 一抗 -
描述
兔多克隆抗体to CYP21A2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide derived from an internal sequence of human CYP21A2.
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阳性对照
- extracts from 293 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab64887于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/100. Detects a band of approximately 56, 40 kDa (predicted molecular weight: 56 kDa).
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说明 |
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WB
1/500 - 1/100. Detects a band of approximately 56, 40 kDa (predicted molecular weight: 56 kDa). |
靶标
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功能
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. -
疾病相关
Adrenal hyperplasia 3 -
序列相似性
Belongs to the cytochrome P450 family. -
结构域
The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane. -
细胞定位
Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 1589 Human
- Omim: 613815 Human
- SwissProt: P08686 Human
- Unigene: 654479 Human
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别名
- CYP21 antibody
- 21 OHase antibody
- 21-OHase antibody
see all
图片
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All lanes : Anti-CYP21A2 antibody (ab64887) at 1/500 dilution
Lane 1 : extracts from 293 cells (5-30µg total protein)
Lane 2 : extracts from 293 cells (5-30µg total protein) and 5-10µg of the immunising peptide.
Predicted band size: 56 kDa
Observed band size: 56 kDa
Additional bands at: 40 kDa. We are unsure as to the identity of these extra bands.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab64887 被引用在 2 文献中.
- Bouhaddioui W et al. CYP21A2 expression is localized in the developing distal epithelium of the human perinatal lung and is compatible with in situ production and intracrine actions of active glucocorticoids. J Steroid Biochem Mol Biol 163:12-9 (2016). PubMed: 27004467
- Idkowiak J et al. Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche. J Clin Endocrinol Metab 95:3418-27 (2010). WB ; Human . PubMed: 20410220