概述

  • 产品名称Anti-CYP11B1抗体
    参阅全部 CYP11B1 一抗
  • 描述
    兔多克隆抗体to CYP11B1
  • 特异性This antibody reacts specifically with 60 kDa CYP11B1 protein.
  • 经测试应用适用于: IHC-Fr, WBmore details
  • 种属反应性
    与反应: Japanese ricefish
  • 免疫原

    Synthetic peptide derived from the C-terminal domain of (Oryzias latipes) CYP11B1.

相关产品

应用

Our Abpromise guarantee covers the use of ab71561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
WB 1/100 - 1/1000. Predicted molecular weight: 60 kDa.Can be blocked with CYP11B1 peptide (ab203375).

靶标

  • 相关性This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. Defects in CYP11B1 are the cause of adrenal hyperplasia type 4 (AH4) [MIM:202010]. AH4 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic). AH4 patients usually have hypertension.
  • 细胞定位Mitochondrion inner membrane.
  • 别名
    • CPN1 antibody
    • CYP11B antibody
    • CYPXIB1 antibody
    • Cytochrome P 450c11 antibody
    • Cytochrome P450 11B1, mitochondrial antibody
    • Cytochrome p450 XIB1 antibody
    • Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody
    • Cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1 antibody
    • Cytochrome P450, subfamily XIB, polypeptide 1 antibody
    • Cytochrome P450C11 antibody
    • FHI antibody
    • P 450C11 antibody
    • P450C11 antibody
    • S11BH antibody
    • Steroid 11 beta hydroxylase antibody
    • Steroid 11 beta monooxygenase antibody
    see all

Anti-CYP11B1 antibody (ab71561)参考文献

This product has been referenced in:
  • Pfennig F  et al. The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression. Reproduction 143:71-84 (2012). IHC ; Tilapia . Read more (PubMed: 22031714) »

See 1 Publication for this product

Product Wall

Thank you for your inquiry.

I can confirm that the immunogen sequence used to develop the ab71561 does not present any homology with proteins from mouse and rat.

The sequence is specific of the C terminal part of Cytochrome P450 11b...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"