Anti-CYP11A1抗体(ab79820)

概述

  • 产品名称Anti-CYP11A1抗体
    参阅全部 CYP11A1 一抗
  • 描述
    兔多克隆抗体to CYP11A1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the N terminal region of human CYP11A1

  • 阳性对照
    • HepG2 cell lysate.

应用

Our Abpromise guarantee covers the use of ab79820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/50 - 1/100. Predicted molecular weight: 60 kDa.

靶标

  • 功能Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
  • 通路Lipid metabolism; C21-steroid hormone metabolism.
  • 疾病相关Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).
    Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.
  • 序列相似性Belongs to the cytochrome P450 family.
  • 细胞定位Mitochondrion membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cholesterol 20 22 desmolase antibody
    • Cholesterol desmolase antibody
    • Cholesterol monooxygenase (side chain cleaving) antibody
    • Cholesterol side chain cleavage enzyme antibody
    • Cholesterol side chain cleavage enzyme mitochondrial antibody
    • Cholesterol side-chain cleavage enzyme antibody
    • CP11A_HUMAN antibody
    • CYP11A antibody
    • CYP11A1 antibody
    • CYPXIA1 antibody
    • Cytochrome P450 11A1 antibody
    • Cytochrome P450 11A1 mitochondrial antibody
    • Cytochrome P450 family 11 subfamily A polypeptide 1 antibody
    • Cytochrome P450 subfamily XIA antibody
    • Cytochrome P450(scc) antibody
    • Cytochrome P450C11A1 antibody
    • mitochondrial antibody
    • P450SCC antibody
    • Steroid 20 22 lyase antibody
    see all

Anti-CYP11A1 antibody 图像

  • Anti-CYP11A1 antibody (ab79820) at 1/50 dilution + HepG2 cell lysate at 35 µg

    Predicted band size : 60 kDa
    Observed band size : 60 kDa
    Additional bands at : 31 kDa. We are unsure as to the identity of these extra bands.

Anti-CYP11A1 antibody (ab79820)参考文献

ab79820 has not yet been referenced specifically in any publications.

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Thank you for your enquiry and your interest in our products. I have conducted a search for you and found some antibodies against CYP11A1. I am not sure if the host and the target species is important for your customer. These are all raised agains...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"