概述

  • 产品名称Anti-CYP11A1抗体
    参阅全部 CYP11A1 一抗
  • 描述
    小鼠多克隆抗体to CYP11A1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-521 of Human CYP11A1

  • 阳性对照
    • CYP11A1 transfected 293T cell lysate.

应用

Our Abpromise guarantee covers the use of ab67355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
    Detection Pair.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
    • 通路Lipid metabolism; C21-steroid hormone metabolism.
    • 疾病相关Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).
      Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.
    • 序列相似性Belongs to the cytochrome P450 family.
    • 细胞定位Mitochondrion membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cholesterol 20 22 desmolase antibody
      • Cholesterol desmolase antibody
      • Cholesterol monooxygenase (side chain cleaving) antibody
      • Cholesterol side chain cleavage enzyme antibody
      • Cholesterol side chain cleavage enzyme mitochondrial antibody
      • Cholesterol side-chain cleavage enzyme antibody
      • CP11A_HUMAN antibody
      • CYP11A antibody
      • CYP11A1 antibody
      • CYPXIA1 antibody
      • Cytochrome P450 11A1 antibody
      • Cytochrome P450 11A1 mitochondrial antibody
      • Cytochrome P450 family 11 subfamily A polypeptide 1 antibody
      • Cytochrome P450 subfamily XIA antibody
      • Cytochrome P450(scc) antibody
      • Cytochrome P450C11A1 antibody
      • mitochondrial antibody
      • P450SCC antibody
      • Steroid 20 22 lyase antibody
      see all

    Anti-CYP11A1 antibody 图像

    • All lanes : Anti-CYP11A1 antibody (ab67355) at 1/500 dilution

      Lane 1 : CYP11A1 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 60 kDa
      Observed band size : 60 kDa
      Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.

    Anti-CYP11A1 antibody (ab67355)参考文献

    This product has been referenced in:
    • Aumo L  et al. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology 151:2151-61 (2010). WB ; Human, Mouse . Read more (PubMed: 20233795) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry and your interest in our products. I have conducted a search for you and found some antibodies against CYP11A1. I am not sure if the host and the target species is important for your customer. These are all raised agains...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"