疾病相关Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI). Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also known as lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant percentage of cases of congenital adrenal hyperplasia.
Cholesterol side chain cleavage enzyme mitochondrial antibody
Cholesterol side-chain cleavage enzyme antibody
Cytochrome P450 11A1 antibody
Cytochrome P450 11A1 mitochondrial antibody
Cytochrome P450 family 11 subfamily A polypeptide 1 antibody
Cytochrome P450 subfamily XIA antibody
Cytochrome P450(scc) antibody
Cytochrome P450C11A1 antibody
Steroid 20 22 lyase antibody
Anti-CYP11A1 antibody 图像
Western blot - CYP11A1 antibody (ab67355)
All lanes : Anti-CYP11A1 antibody (ab67355) at 1/500 dilution
Lane 1 : CYP11A1 transfected 293T cell lysate Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 60 kDa Observed band size : 60 kDa Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.
Anti-CYP11A1 antibody (ab67355)参考文献
This product has been referenced in:
Aumo L et al. Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology151:2151-61 (2010).
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