概述

  • 产品名称Anti-CYLD抗体
    参阅全部 CYLD 一抗
  • 描述
    山羊多克隆抗体to CYLD
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Horse, Cow, Dog, Human, Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide:

    C-DSQQSKSKNPWYIDE

    , corresponding to internal sequence amino acids 361-375 of Mouse CYLD

  • 阳性对照
    • Brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab60266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 120 kDa (predicted molecular weight: 107 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis.
    • 组织特异性Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.
    • 疾病相关Defects in CYLD are the cause of familial cylindromatosis (FCYL) [MIM:132700]; also known as Ancell-Spiegler cylindromas or turban tumor syndrome or dermal eccrine cylindromatosis. CYLD is an autosomal dominant and highly tumor type-specific disorder. The tumors (known as cylindromas because of their characteristic microscopic architecture) are believed to arise from or recapitulate the appearance of the eccrine or apocrine cells of the skin that secrete sweat and scent respectively. Cylindromas arise predominantly in hairy parts of the body with approximately 90% on the head and neck. The development of a confluent mass which may ulcerate or become infected has led to the designation 'turban tumor syndrome'. The skin tumors show differentiation in the direction of hair structures, hence the synonym trichoepithelioma.
      Defects in CYLD are the cause of multiple familial trichoepithelioma type 1 (MFT1) [MIM:601606]; also known as epithelioma adenoides cysticum of Brooke (EAC) or hereditary multiple benign cystic epithelioma or Brooke-Fordyce trichoepitheliomas. MFT1 is an autosomal dominant dermatosis characterized by the presence of many skin tumors predominantly on the face. Since histologic examination shows dermal aggregates of basaloid cells with connection to or differentiation toward hair follicles, this disorder has been thought to represent a benign hamartoma of the pilosebaceous apparatus. Trichoepitheliomas can degenerate into basal cell carcinoma.
      Defects in CYLD are the cause of Brooke-Spiegler syndrome (BRSS) [MIM:605041]. BRSS is an autosomal dominant disorder characterized by the appearance of multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. These tumors are typically located in the head and neck region, appear in early adulthood, and gradually increase in size and number throughout life.
    • 序列相似性Belongs to the peptidase C67 family.
      Contains 3 CAP-Gly domains.
    • 翻译后修饰Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli. Phosphorylation requires IKBKG. Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.
    • 细胞定位Cytoplasm. Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton. Cell membrane. Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BRSS antibody
      • CDMT antibody
      • Cyld antibody
      • CYLD gene antibody
      • CYLD_HUMAN antibody
      • CYLD1 antibody
      • CYLDI antibody
      • cylindromatosis (turban tumor syndrome) antibody
      • cylindromatosis 1 antibody
      • Deubiquitinating enzyme CYLD antibody
      • EAC antibody
      • HSPC057 antibody
      • KIAA0849 antibody
      • MFT antibody
      • MFT1 antibody
      • Probable ubiquitin carboxyl terminal hydrolase CYLD antibody
      • SBS antibody
      • TEM antibody
      • turban tumor syndrome antibody
      • Ubiquitin carboxyl-terminal hydrolase CYLD antibody
      • ubiquitin specific peptidase like 2 antibody
      • ubiquitin thioesterase CYLD antibody
      • Ubiquitin thiolesterase CYLD antibody
      • Ubiquitin-specific processing protease CYLD antibody
      • Ubiquitin-specific-processing protease CYLD antibody
      • USPL2 antibody
      see all

    Anti-CYLD antibody 图像

    Anti-CYLD antibody (ab60266)参考文献

    ab60266 has not yet been referenced specifically in any publications.

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