概述

  • 产品名称Anti-CYFIP2抗体
    参阅全部 CYFIP2 一抗
  • 描述
    兔多克隆抗体to CYFIP2
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Zebrafish
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 346-610 of Human CYFIP2 (UniProt ID: Q96F07 isoform 2; NP_055191).

  • 阳性对照
    • WB: MOLT4 whole cell lysate; Raji cell lysate IHC-P: NCIN87 xenograft

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab95969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 146 kDa.
IHC-P 1/100 - 1/500.
ICC/IF Use at an assay dependent concentration. PubMed: 24658146

靶标

  • 相关性CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing.
  • 细胞定位Cytoplasm perinuclear region. Cell junction, synapse, synaptosome. Treatment with leptomycin-B triggers translocation to the nucleus.
  • 数据库链接
  • 别名
    • CYFP2 antibody
    • cytoplasmic FMR1 interacting protein 2 antibody
    • KIAA1168 antibody
    • p53 inducible protein antibody
    • p53-inducible protein 121 antibody
    • PIR121 antibody
    see all

Anti-CYFIP2 antibody 图像

  • Anti-CYFIP2 antibody (ab95969) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 146 kDa
  • ab95969, at a 1/100 dilution, staining CYFIP2 in paraffin embedded NCIN87 xenograft by Immunohistochemistry.

Anti-CYFIP2 antibody (ab95969)参考文献

This product has been referenced in:
  • Taha MS  et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS One 9:e91465 (2014). ICC/IF ; Human . Read more (PubMed: 24658146) »
  • Han K  et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503:72-7 (2013). Mouse . Read more (PubMed: 24153177) »

See all 3 Publications for this product

Product Wall

Thank you for contacting us. As a general guidance, I can make some suggestions in order to improve the results from this antibody. As a lysis buffer I would suggest using RIPA (radio immuno precipitation assay) buffer. You can prepare it following the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"