概述

  • 产品名称
    Anti-Cyclophilin 40抗体
    参阅全部 Cyclophilin 40 一抗
  • 描述
    兔多克隆抗体to Cyclophilin 40
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat, Rabbit, Human
    预测可用于: Mouse, Cow
  • 免疫原

    Synthetic peptide corresponding to Human Cyclophilin 40 aa 57-71.
    Sequence:

    GIGHTTGKPLHFKGC

  • 阳性对照
    • Rat brain extract.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • 纯度
    Whole antiserum
  • Primary antibody说明
    Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab5903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 40 kDa (predicted molecular weight: 44 kDa).

Detects a band of approximately 40 kDa representing CyP-40 from rat brain extract.

靶标

  • 功能
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
    Contains 1 PPIase cyclophilin-type domain.
    Contains 3 TPR repeats.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 40 kDa peptidyl prolyl cis trans isomerase antibody
    • 40 kDa peptidyl prolyl cis trans isomerase D antibody
    • 40 kDa peptidyl-prolyl cis-trans isomerase antibody
    • Cyclophilin D antibody
    • Cyclophilin related protein antibody
    • Cyclophilin-40 antibody
    • Cyclophilin-related protein antibody
    • Cyclophilin40 antibody
    • CyclophilinD antibody
    • CYP 40 antibody
    • CYP-40 antibody
    • CYP40 antibody
    • CYPD antibody
    • MGC33096 antibody
    • Peptidyl Prolyl Isomerase D antibody
    • Peptidyl-prolyl cis-trans isomerase D antibody
    • Peptidylprolyl isomerase D antibody
    • PPIase antibody
    • PPIase D antibody
    • Ppid antibody
    • PPID_HUMAN antibody
    • Rotamase antibody
    • Rotamase D antibody
    see all

实验方案

文献

This product has been referenced in:
  • Honoré B  et al. Identification of differentially expressed proteins in spontaneous thymic lymphomas from knockout mice with deletion of p53. Proteome Sci 6:18 (2008). WB . Read more (PubMed: 18544163) »

See 1 Publication for this product

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