Anti-Cyclin Y抗体(ab114086)
Key features and details
- Rabbit polyclonal to Cyclin Y
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-Cyclin Y抗体
参阅全部 Cyclin Y 一抗 -
描述
兔多克隆抗体to Cyclin Y -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat -
免疫原
Synthetic peptide corresponding to Human Cyclin Y. Between aa 291 and 341
Database link: Q8ND76 -
阳性对照
- HeLa, 293T, NIH 3T3 and MCF7 whole cell lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7-8 -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab114086 was affinity purified using an epitope specific to Cyclin Y immobilized on solid support. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab114086于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/2500. Predicted molecular weight: 39 kDa.
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说明 |
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WB
1/500 - 1/2500. Predicted molecular weight: 39 kDa. |
靶标
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功能
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. -
组织特异性
Widely expressed. -
序列相似性
Belongs to the cyclin family. Cyclin Y subfamily.
Contains 1 cyclin N-terminal domain. -
发展阶段
Enriched at G2/M. -
翻译后修饰
Ubiquitinated; leading to its degradation.
Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. -
细胞定位
Nucleus and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 613711 Cow
- Entrez Gene: 219771 Human
- Entrez Gene: 67974 Mouse
- Omim: 612786 Human
- SwissProt: Q8ND76 Human
- SwissProt: Q8BGU5 Mouse
- Unigene: 14745 Human
- Unigene: 564123 Human
see all -
别名
- C10orf9 antibody
- CBCP1 antibody
- CCNX antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab114086 被引用在 2 文献中.
- Gasa L et al. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. Sci Rep 7:10228 (2017). PubMed: 28860486
- Yan F et al. RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth. Oncol Rep 36:2793-2799 (2016). PubMed: 27666310