概述

  • 产品名称Anti-Cyclin E1抗体
    参阅全部 Cyclin E1 一抗
  • 描述
    兔多克隆抗体to Cyclin E1
  • 特异性This antibody detects endogenous levels of total Cyclin E1 protein.
  • 经测试应用适用于: ELISA, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to Human Cyclin E1. Immunogen range is aa 43-92
    Database link: P24864

  • 阳性对照
    • Hela cells

性能

应用

Our Abpromise guarantee covers the use of ab62624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
ICC/IF 1/100 - 1/500.
IHC-P 1/50 - 1/100.

靶标

  • 功能Essential for the control of the cell cycle at the G1/S (start) transition.
  • 组织特异性Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
  • 序列相似性Belongs to the cyclin family. Cyclin E subfamily.
  • 翻译后修饰Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CCNE antibody
    • Ccne1 antibody
    • CCNE1_HUMAN antibody
    • cyclin E variant ex5del antibody
    • cyclin E variant ex7del antibody
    • Cyclin E1 antibody
    • Cyclin Es antibody
    • Cyclin Et antibody
    • CyclinE antibody
    • G1/S specific cyclin E antibody
    • G1/S-specific cyclin-E1 antibody
    see all

Anti-Cyclin E1 antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human heart tissue, using ab62624 at 1/50 dilution. The picture on the right is blocked with the synthesized peptide.

  • Immunofluorescence analysis of HeLa cells, using ab62624 at a 1:500 dilution.

    Left image untreated.

    Right image treated with peptide.

Anti-Cyclin E1 antibody (ab62624)参考文献

ab62624 has not yet been referenced specifically in any publications.

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