概述

  • 产品名称Anti-Cyclin E1抗体
    参阅全部 Cyclin E1 一抗
  • 描述
    兔多克隆抗体to Cyclin E1
  • 特异性ab52239 detects endogenous levels of total Cyclin E1 protein.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human Cyclin E1. Immunogen range is 91-140

  • 阳性对照
    • K562 cells.

性能

应用

Our Abpromise guarantee covers the use of ab52239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/300 - 1/1000. Detects a band of approximately 49 kDa (predicted molecular weight: 47 kDa).
ELISA 1/20000.

靶标

  • 功能Essential for the control of the cell cycle at the G1/S (start) transition.
  • 组织特异性Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
  • 序列相似性Belongs to the cyclin family. Cyclin E subfamily.
  • 翻译后修饰Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CCNE antibody
    • Ccne1 antibody
    • CCNE1_HUMAN antibody
    • cyclin E variant ex5del antibody
    • cyclin E variant ex7del antibody
    • Cyclin E1 antibody
    • Cyclin Es antibody
    • Cyclin Et antibody
    • CyclinE antibody
    • G1/S specific cyclin E antibody
    • G1/S-specific cyclin-E1 antibody
    see all

Anti-Cyclin E1 antibody 图像

  • All lanes : Anti-Cyclin E1 antibody (ab52239) at 1/300 dilution

    Lane 1 : K562 cell extract; without peptide
    Lane 2 : K562 cell extract; with peptide


    Predicted band size : 47 kDa
    Observed band size : 49 kDa (why is the actual band size different from the predicted?)

Anti-Cyclin E1 antibody (ab52239)参考文献

ab52239 has not yet been referenced specifically in any publications.

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