Anti-Cyclin D3抗体[SPM241], prediluted (ab54238)

概述

  • 产品名称Anti-Cyclin D3抗体[SPM241], prediluted
    参阅全部 Cyclin D3 一抗
  • 描述
    小鼠单克隆抗体[SPM241] to Cyclin D3, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human, Monkey
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant full length protein (Human)

  • 阳性对照
    • LS174T cells. Human breast carcinoma or tonsil tissue.

性能

应用

Our Abpromise guarantee covers the use of ab54238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready to use for 30 min at room temperature.
    Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    • 序列相似性Belongs to the cyclin family. Cyclin D subfamily.
      Contains 1 cyclin N-terminal domain.
    • 细胞定位Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CCND 3 antibody
      • Ccnd3 antibody
      • CCND3_HUMAN antibody
      • CyclinD3 antibody
      • D3 type cyclin antibody
      • G1 S specific cyclin D3 antibody
      • G1/S specific cyclin D3 antibody
      • G1/S-specific cyclin-D3 antibody
      see all

    Anti-Cyclin D3 antibody [SPM241], prediluted 图像

    • Ab54238, prediluted, staining Cyclin D3 in formalin fixed, paraffin embedded human tonsil tissue by immunohistochemistry.

    Anti-Cyclin D3 antibody [SPM241], prediluted (ab54238)参考文献

    ab54238 has not yet been referenced specifically in any publications.

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