RabMAb

Anti-Cyclin D1抗体[SP4], prediluted (ab21699)

概述

  • 产品名称Anti-Cyclin D1抗体[SP4], prediluted
    参阅全部 Cyclin D1 一抗
  • 描述
    兔单克隆抗体[SP4] to Cyclin D1, prediluted
  • 特异性ab21699 recognises Cyclin D1.
  • 经测试应用适用于: IHC-P, IHC-Fr, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide from C-terminus of human cyclin D1.

  • 阳性对照
    • Breast carcinoma, mantle cell lymphoma. MCF7 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab21699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use at an assay dependent concentration.
WB 1/25. Predicted molecular weight: 34 kDa.

靶标

  • 功能Essential for the control of the cell cycle at the G1/S (start) transition.
  • 疾病相关Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
    Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.
    Defects in CCND1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.
  • 序列相似性Belongs to the cyclin family. Cyclin D subfamily.
  • 翻译后修饰Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
    Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB (By similarity). Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to stabilize it.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI327039 antibody
    • B cell CLL/lymphoma 1 antibody
    • B cell leukemia 1 antibody
    • B cell lymphoma 1 protein antibody
    • B-cell lymphoma 1 protein antibody
    • BCL 1 antibody
    • BCL-1 antibody
    • BCL-1 oncogene antibody
    • BCL1 antibody
    • BCL1 oncogene antibody
    • ccnd1 antibody
    • CCND1/FSTL3 fusion gene, included antibody
    • CCND1/IGHG1 fusion gene, included antibody
    • CCND1/IGLC1 fusion gene, included antibody
    • CCND1/PTH fusion gene, included antibody
    • CCND1_HUMAN antibody
    • cD1 antibody
    • Cyl 1 antibody
    • D11S287E antibody
    • G1/S specific cyclin D1 antibody
    • G1/S-specific cyclin-D1 antibody
    • Parathyroid adenomatosis 1 antibody
    • PRAD1 antibody
    • PRAD1 oncogene antibody
    • U21B31 antibody
    see all

Anti-Cyclin D1 antibody [SP4], prediluted 图像

  • Anti-Cyclin D1 antibody [SP4], prediluted (ab21699) at 1/25 dilution + MCF7 cell lysate

    Predicted band size : 34 kDa
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Mantle Cell Lymphoma tissue, staining Cyclin D1 with ab21699 at 1/100 dilution.
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue, staining Cyclin D1 with ab21699 at 1/100 dilution.
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human endometrial adenocarcinoma tissue, staining Cyclin D1 with ab21699 at 1/100 dilution.
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung adenocarcinoma tissue, staining Cyclin D1 with ab21699 at 1/100 dilution.

Anti-Cyclin D1 antibody [SP4], prediluted (ab21699)参考文献

This product has been referenced in:
  • Munkley J  et al. The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. Oncoscience 2:755-64 (2015). Read more (PubMed: 26501081) »
  • Vessey KA  et al. Adenosine triphosphate-induced photoreceptor death and retinal remodeling in rats. J Comp Neurol 522:2928-50 (2014). IHC-FoFr ; Rat . Read more (PubMed: 24639102) »

See all 4 Publications for this product

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