概述

  • 产品名称Anti-Cyclin C抗体
    参阅全部 Cyclin C 一抗
  • 描述
    兔多克隆抗体to Cyclin C
  • 经测试应用适用于: WB, IP, ICC/IF, Functional Studiesmore details
  • 种属反应性
    与反应: Mouse, Rat, Dog, Human
    预测可用于: Chicken, Cow, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to Human Cyclin C aa 270-283 (C terminal) (Cysteine residue).
    Sequence:

    C-QGPNGSQNSSYSQS

  • 阳性对照
    • HeLa cells

性能

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应用

Our Abpromise guarantee covers the use of ab80910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 5 - 10 µg/ml. Predicted molecular weight: 33 kDa.
IP Use at 10 µg/mg of lysate.
ICC/IF Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.

Kinase assay.

靶标

  • 功能Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 组织特异性Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 序列相似性Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

Anti-Cyclin C antibody (ab80910)参考文献

ab80910 has not yet been referenced specifically in any publications.

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