概述

  • 产品名称Anti-Cyclin C抗体
    参阅全部 Cyclin C 一抗
  • 描述
    兔多克隆抗体to Cyclin C
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide derived from the C terminal region of Human Cyclin C (NP_005181.2)

  • 阳性对照
    • Pancreatic islet cell tumor or skin squamous cell carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab105046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. Likely to work with frozen sections

靶标

  • 功能Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
  • 组织特异性Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
  • 序列相似性Belongs to the cyclin family. Cyclin C subfamily.
    Contains 1 cyclin N-terminal domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ccnc antibody
    • CCNC_HUMAN antibody
    • CycC antibody
    • Cyclin C antibody
    • Cyclin-C antibody
    • hSRB11 antibody
    • OTTHUMP00000016897 antibody
    • SRB11 homolog antibody
    see all

Anti-Cyclin C antibody 图像

  • ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, paraffin-embedded Human skin squamous cell carcinomatissue.
    Detection: DAB staining.
  • ab105046 at 1/100 dilution staining Cyclin C in formalin-fixed, pParaffin-embedded Human pancreatic islet cell tumor tissue.
    Detection: DAB staining.

Anti-Cyclin C antibody (ab105046)参考文献

ab105046 has not yet been referenced specifically in any publications.

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