概述

  • 产品名称Anti-CYB5R3抗体
    参阅全部 CYB5R3 一抗
  • 描述
    山羊多克隆抗体to CYB5R3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Cow, Dog, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    CLPNLERVGHPKER

    , corresponding to C terminal amino acids 284-297 of Mouse CYB5R3 (NP_084063.1).

  • 阳性对照
    • Mouse and Rat Lung lysates.

性能

应用

Our Abpromise guarantee covers the use of ab112513 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 34 kDa.

靶标

  • 功能Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
  • 组织特异性Isoform 2 is expressed at late stages of erythroid maturation.
  • 疾病相关Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:250800]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.
  • 序列相似性Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    Contains 1 FAD-binding FR-type domain.
  • 细胞定位Endoplasmic reticulum membrane. Mitochondrion outer membrane and Cytoplasm. Produces the soluble form found in erythrocytes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • B5R antibody
    • Cyb5r3 antibody
    • Cytochrome b5 reductase 3 antibody
    • Cytochrome b5 reductase antibody
    • DIA1 antibody
    • Diaphorase 1 antibody
    • Diaphorase-1 antibody
    • NADH cytochrome b5 reductase 3 antibody
    • NADH-cytochrome b5 reductase 3 membrane-bound form antibody
    • NADH-cytochrome b5 reductase 3 soluble form antibody
    • NB5R3_HUMAN antibody
    • OTTHUMP00000028761 antibody
    • OTTHUMP00000198435 antibody
    • OTTHUMP00000198574 antibody
    • OTTHUMP00000198662 antibody
    • OTTHUMP00000198665 antibody
    see all

Anti-CYB5R3 antibody 图像

  • Anti-CYB5R3 antibody (ab112513) at 0.1 µg/ml + Mouse Lung lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 34 kDa

Anti-CYB5R3 antibody (ab112513)参考文献

ab112513 has not yet been referenced specifically in any publications.

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