Anti-CXXC4抗体(ab105400)
Key features and details
- Rabbit polyclonal to CXXC4
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CXXC4抗体 -
描述
兔多克隆抗体to CXXC4 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, ICC/IF, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide of 18 amino acids near the N terminal end of Human CXXC4 (NP_079488).
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阳性对照
- Human brain tissue lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. The product can be stored for up to 12 months. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105400于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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ICC/IF |
Use a concentration of 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
ICC/IF
Use a concentration of 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa. |
靶标
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功能
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. -
序列相似性
Contains 1 CXXC-type zinc finger. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 80319 Human
- Entrez Gene: 319478 Mouse
- Entrez Gene: 83824 Rat
- Omim: 611645 Human
- SwissProt: Q9H2H0 Human
- SwissProt: Q6NXI8 Mouse
- SwissProt: Q9EQC9 Rat
- Unigene: 12248 Human
see all -
别名
- CXXC finger 4 antibody
- CXXC finger protein 4 antibody
- CXXC type zinc finger protein 4 antibody
see all
图片
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Immunofluorescence of CXXC4 in Human brain tissue with ab105400 at 20ug/mL.
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Immunohistochemistry of CXXC4 in Human brain tissue with ab105400 at 10 μg/mL.
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All lanes : Anti-CXXC4 antibody (ab105400) at 1 µg/ml
Lane 1 : Human brain tissue lysate
Lane 2 : Human brain tissue lysate with CXXC4 peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 21 kDa
实验方案
数据表及文件
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Datasheet download
文献 (7)
ab105400 被引用在 7 文献中.
- He Y et al. A noncanonical AR addiction drives enzalutamide resistance in prostate cancer. Nat Commun 12:1521 (2021). PubMed: 33750801
- Liu S et al. Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma. J Cancer 11:6288-6298 (2020). PubMed: 33033513
- Byun HJ et al. LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer. Yonsei Med J 61:923-934 (2020). PubMed: 33107235
- Li P et al. GC-Derived EVs Enriched with MicroRNA-675-3p Contribute to the MAPK/PD-L1-Mediated Tumor Immune Escape by Targeting CXXC4. Mol Ther Nucleic Acids 22:615-626 (2020). PubMed: 33230461
- Li P et al. CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway. J Cell Mol Med 24:10151-10165 (2020). PubMed: 32715641
- Lu J et al. MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4. Biosci Rep 38:N/A (2018). PubMed: 30042169
- Kojima T et al. Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. Oncogene 28:297-305 (2009). PubMed: 18931698