概述

  • 产品名称
    Anti-Cullin 7抗体
    参阅全部 Cullin 7 一抗
  • 描述
    兔多克隆抗体to Cullin 7
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 1370-1679 of Human Cullin 7

  • 阳性对照
    • H1299, HeLa, HepG2, Molt-4, Raji

性能

应用

Our Abpromise guarantee covers the use of ab96861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 191 kDa.

靶标

  • 功能
    Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.
  • 组织特异性
    Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.
  • 通路
    Protein modification; protein ubiquitination.
  • 疾病相关
    Defects in CUL7 are the cause of 3M syndrome type 1 (3M1) [MIM:273750]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.
  • 序列相似性
    Belongs to the cullin family.
    Contains 1 DOC domain.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CUL-7 antibody
    • CUL7 antibody
    • CUL7_HUMAN antibody
    • Cullin-7 antibody
    • dJ20C7.5 antibody
    • KIAA0076 antibody
    see all

图片

  • Anti-Cullin 7 antibody (ab96861) at 1/1000 dilution + Molt-4 cell lysate at 30 µg

    Predicted band size : 191 kDa

实验方案

文献

ab96861 has not yet been referenced specifically in any publications.

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