概述

  • 产品名称Anti-Cullin 7抗体
    参阅全部 Cullin 7 一抗
  • 描述
    兔多克隆抗体to Cullin 7
  • 经测试应用适用于: WB, IP, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Cow, Pig, Orangutan
  • 免疫原

    Synthetic peptide:

    RSRGVPYASCTATQSFSTFR

    conjugated to KLH, corresponding to C terminal amino acids 1679-1698 of Human Cullin 7

  • 阳性对照
    • Human Brain, Cortex tissue

性能

应用

Our Abpromise guarantee covers the use of ab115304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 191 kDa.
IP Use at an assay dependent concentration.
IHC-P 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA 1/2000 - 1/10000.

靶标

  • 功能Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.
  • 组织特异性Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Defects in CUL7 are the cause of 3M syndrome type 1 (3M1) [MIM:273750]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.
  • 序列相似性Belongs to the cullin family.
    Contains 1 DOC domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CUL-7 antibody
    • CUL7 antibody
    • CUL7_HUMAN antibody
    • Cullin-7 antibody
    • dJ20C7.5 antibody
    • KIAA0076 antibody
    see all

Anti-Cullin 7 antibody 图像

  • ab115304, at 1/500 dilution, staining Cullin 7 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Cullin 7 antibody (ab115304)参考文献

ab115304 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115304.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"