Anti-Cullin 7/CUL-7抗体(ab115304)
Key features and details
- Rabbit polyclonal to Cullin 7/CUL-7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Cullin 7/CUL-7抗体
参阅全部 Cullin 7/CUL-7 一抗 -
描述
兔多克隆抗体to Cullin 7/CUL-7 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Rat, Horse, Cow, Pig, Orangutan -
免疫原
Synthetic peptide corresponding to Human Cullin 7/CUL-7 aa 1650-1750 (C terminal) conjugated to keyhole limpet haemocyanin.
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阳性对照
- Human Brain, Cortex tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 6
Preservative: 0.01% Sodium azide
Constituent: 99% Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
纯化说明
Delipidation and defibrination -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115304于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. -
组织特异性
Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. -
通路
Protein modification; protein ubiquitination. -
疾病相关
Defects in CUL7 are the cause of 3M syndrome type 1 (3M1) [MIM:273750]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. -
序列相似性
Belongs to the cullin family.
Contains 1 DOC domain. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 504558 Cow
- Entrez Gene: 100067262 Horse
- Entrez Gene: 9820 Human
- Entrez Gene: 100172168 Orangutan
- Entrez Gene: 363191 Rat
- Omim: 609577 Human
- SwissProt: Q14999 Human
- SwissProt: Q5RCJ3 Orangutan
see all -
别名
- CUL-7 antibody
- CUL7 antibody
- CUL7_HUMAN antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab115304 尚未被引用在任何文献中。