概述

  • 产品名称Anti-Cullin 2抗体
    参阅全部 Cullin 2 一抗
  • 描述
    山羊多克隆抗体to Cullin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Cow, Dog, Human
  • 免疫原

    Synthetic peptide:

    QYIERSQASADE

    by a Cysteine residue linker, corresponding to C terminal amino acids 729-740 of Human Cullin 2 (NP_003582.2)

  • 阳性对照
    • NIH3T3 lysate

性能

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应用

Our Abpromise guarantee covers the use of ab101712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 87 kDa.

靶标

  • 功能Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the cullin family.
  • 翻译后修饰CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cul2 antibody
    • CUL 2 antibody
    • CUL-2 antibody
    • CUL2 antibody
    • CUL2_HUMAN antibody
    • cullin 2 antibody
    • cullin homolog 2 antibody
    • Cullin-2 antibody
    • MGC131970 antibody
    see all

Anti-Cullin 2 antibody 图像

  • Anti-Cullin 2 antibody (ab101712) at 1 µg/ml + NIH3T3 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa

Anti-Cullin 2 antibody (ab101712)参考文献

ab101712 has not yet been referenced specifically in any publications.

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