Anti-Cullin 1抗体[AS97.1] (ab115187)

概述

  • 产品名称Anti-Cullin 1抗体[AS97.1]
    参阅全部 Cullin 1 一抗
  • 描述
    小鼠单克隆抗体[AS97.1] to Cullin 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Cow, Human, Monkey
  • 免疫原

    Recombinant Human Cullin 1.

性能

应用

Our Abpromise guarantee covers the use of ab115187 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/250. Predicted molecular weight: 90 kDa.

靶标

  • 功能Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
  • 组织特异性Expressed in lung fibroblasts.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the cullin family.
  • 翻译后修饰Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CUL 1 antibody
    • CUL-1 antibody
    • CUL1 antibody
    • CUL1_HUMAN antibody
    • Cullin-1 antibody
    • Cullin1 antibody
    • MGC149834 antibody
    • MGC149835 antibody
    see all

Anti-Cullin 1 antibody [AS97.1] (ab115187)参考文献

ab115187 has not yet been referenced specifically in any publications.

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