Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 4-34 of Human CTDSPL (NP_001008393.1 , NP_005799.2).
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium Azide
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Immunogen affinity purified
Purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 31 kDa.
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Expression is restricted to non-neuronal tissues.
Contains 1 FCP1 homology domain.
Information by UniProt
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3 antibody
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like antibody
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"