概述

  • 产品名称Anti-CSRP3抗体
    参阅全部 CSRP3 一抗
  • 描述
    山羊多克隆抗体to CSRP3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Cow, Dog, Zebrafish
  • 免疫原

    Synthetic peptide:

    CGKSLESTNVTDKD

    , corresponding to internal sequence amino acids 150-163 of Human CSRP3 (NP_003467.1).

  • 阳性对照
    • Human, mouse and rat heart lysates.

性能

应用

Our Abpromise guarantee covers the use of ab81814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).

靶标

  • 功能Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
  • 组织特异性Cardiac and slow-twitch skeletal muscles.
  • 疾病相关Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M) [MIM:607482]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in CSRP3 are the cause of cardiomyopathy familial hypertrophic type 12 (CMH12) [MIM:612124]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Contains 2 LIM zinc-binding domains.
  • 细胞定位Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cardiac antibody
    • Cardiac LIM protein antibody
    • CLP antibody
    • CMD1M antibody
    • CMH12 antibody
    • CRP3 antibody
    • Csrp3 antibody
    • CSRP3_HUMAN antibody
    • Cysteine and glycine-rich protein 3 antibody
    • Cysteine rich protein 3 antibody
    • Cysteine-rich protein 3 antibody
    • LIM domain only 4 antibody
    • LIM domain protein antibody
    • LMO4 antibody
    • MLP antibody
    • Muscle LIM protein antibody
    see all

Anti-CSRP3 antibody 图像

  • Anti-CSRP3 antibody (ab81814) at 0.01 µg/ml + Rat heart lysate in RIPA buffer at 35 µg

    Predicted band size : 21 kDa
    Observed band size : 21 kDa

Anti-CSRP3 antibody (ab81814)参考文献

ab81814 has not yet been referenced specifically in any publications.

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