概述

  • 产品名称Anti-CSRP3抗体
    参阅全部 CSRP3 一抗
  • 描述
    小鼠单克隆抗体to CSRP3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: SPKPARSVTT SNPSKFTAKF GESEKCPRCG KSVYAAEKVM GGGKPWHKTC FRCAICGKSL ESTNVTDKDG ELYCKVCYAK NFGPTGIGFG GLTQQVEKKE , corresponding to amino acids 95-195 of Human CSRP3

性能

应用

Our Abpromise guarantee covers the use of ab56368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
    • 组织特异性Cardiac and slow-twitch skeletal muscles.
    • 疾病相关Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M) [MIM:607482]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in CSRP3 are the cause of cardiomyopathy familial hypertrophic type 12 (CMH12) [MIM:612124]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • 序列相似性Contains 2 LIM zinc-binding domains.
    • 细胞定位Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3.
    • Information by UniProt
    • 数据库链接
    • 别名
      • cardiac antibody
      • Cardiac LIM protein antibody
      • CLP antibody
      • CMD1M antibody
      • CMH12 antibody
      • CRP3 antibody
      • Csrp3 antibody
      • CSRP3_HUMAN antibody
      • Cysteine and glycine-rich protein 3 antibody
      • Cysteine rich protein 3 antibody
      • Cysteine-rich protein 3 antibody
      • LIM domain only 4 antibody
      • LIM domain protein antibody
      • LMO4 antibody
      • MLP antibody
      • Muscle LIM protein antibody
      see all

    Anti-CSRP3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56368 CSRP3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-CSRP3 antibody (ab56368)参考文献

    This product has been referenced in:
    • McCully JD  et al. Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart. Physiol Genomics 38:125-37 (2009). WB ; Rabbit . Read more (PubMed: 19454556) »

    See 1 Publication for this product

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