概述

  • 产品名称Anti-CSN7b抗体
    参阅全部 CSN7b 一抗
  • 描述
    小鼠多克隆抗体to CSN7b
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human CSN7b (NP_073567.1, amino acids 1-264)

  • 阳性对照
    • HeLa cell lysate, CSN7b transfected 293T cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab89645 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa.

靶标

  • 功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 序列相似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • COP9 Complex Homolog Subunit 7b antibody
    • COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody
    • COP9 Signalasome Subunit 7b antibody
    • COP9 signalosome complex subunit 7b antibody
    • COPS7B antibody
    • CSN7B_HUMAN antibody
    • JAB1 Containing Signalosome Subunit 7b antibody
    • JAB1-containing signalosome subunit 7b antibody
    • SGN7b antibody
    • Signalosome subunit 7b antibody
    see all

Anti-CSN7b antibody 图像

  • Anti-CSN7b antibody (ab89645) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 32 kDa
    Observed band size : 28 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-CSN7b antibody (ab89645) at 1 µg/ml

    Lane 1 : CSN7b transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 32 kDa
    Observed band size : 32 kDa

Anti-CSN7b antibody (ab89645)参考文献

ab89645 has not yet been referenced specifically in any publications.

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