概述

  • 产品名称Anti-CSN7b抗体
    参阅全部 CSN7b 一抗
  • 描述
    兔多克隆抗体to CSN7b
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • 免疫原

    Immunogen was a synthetic peptide, which represented a portion of human constitutive photomorphogenic homolog 7b encoded within exon 10.

性能

应用

Our Abpromise guarantee covers the use of ab11895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 33 kDa.

靶标

  • 功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 序列相似性Belongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • COP9 Complex Homolog Subunit 7b antibody
    • COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody
    • COP9 Signalasome Subunit 7b antibody
    • COP9 signalosome complex subunit 7b antibody
    • COPS7B antibody
    • CSN7B_HUMAN antibody
    • JAB1 Containing Signalosome Subunit 7b antibody
    • JAB1-containing signalosome subunit 7b antibody
    • SGN7b antibody
    • Signalosome subunit 7b antibody
    see all

Anti-CSN7b antibody 图像

  • RIPA lysate (50µg for E; 25µg for T) from HEK293T cells that were mock transfected (E) or transfected with a CSN7b construct (T). Antibody: ab11895 used at the indicated concentration. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-CSN7b antibody (ab11895)参考文献

This product has been referenced in:
  • Oh W  et al. Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem 281:17457-65 (2006). Read more (PubMed: 16624822) »

See 1 Publication for this product

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