概述

  • 产品名称Anti-CSN3抗体
    参阅全部 CSN3 一抗
  • 描述
    兔多克隆抗体to CSN3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY) of Human CSN3 (NP_005203).

  • 阳性对照
    • Jurkat cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab111406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 20 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性CSN3 is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • Casein Kappa antibody
    • COP9 Signalosome Complex Subunit 3 antibody
    • COPS3 antibody
    • CSN10 antibody
    • CSNK antibody
    • JAB1 Containing Signalosome Subunit 3 antibody
    • kappa-casein antibody
    • KCA antibody
    • SGN3 antibody
    • Signalosome Subunit 3 antibody
    see all

Anti-CSN3 antibody 图像

  • Anti-CSN3 antibody (ab111406) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 20 kDa

Anti-CSN3 antibody (ab111406)参考文献

ab111406 has not yet been referenced specifically in any publications.

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