概述

描述

  • 性质
    Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab55818 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CSEN antibody (ab41717)

    Western blot

  • 纯度
    > 90 % SDS-PAGE.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • 4933407H12Rik
    • A type potassium channel modulatory protein 3
    • A-type potassium channel modulatory protein 3
    • AI413860
    • Calsenilin
    • CSEN
    • CSEN_HUMAN
    • DRE antagonist modulator
    • DRE-antagonist modulator
    • DREAM
    • EF hand transcription factor
    • KCHIP 3
    • KChIP3
    • KCNIP 3
    • Kcnip3
    • Kv channel interacting protein 3
    • Kv channel-interacting protein 3
    • MGC18289
    • Potassium channel interacting protein 3
    • R74849
    see all
  • 功能
    Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
    May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
  • 组织特异性
    Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
  • 序列相似性
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 翻译后修饰
    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
    Proteolytically cleaved by caspase-3.
    Phosphorylation at Ser-63 inhibits cleavage by CASP3.
  • 细胞定位
    Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
  • Information by UniProt

文献

ab55818 has not yet been referenced specifically in any publications.

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