概述

  • 产品名称Anti-CSEN抗体
    参阅全部 CSEN 一抗
  • 描述
    兔多克隆抗体to CSEN
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide surrounding amino acid 107 of human CSEN.

  • 阳性对照
    • Jurkat cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab41717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 2 - 6 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 29 kDa).

    Can be blocked with CSEN peptide (ab55818).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
      Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
      May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
    • 组织特异性Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
    • 序列相似性Belongs to the recoverin family.
      Contains 4 EF-hand domains.
    • 翻译后修饰Palmitoylated. Palmitoylation enhances association with the plasma membrane.
      Proteolytically cleaved by caspase-3.
      Phosphorylation at Ser-63 inhibits cleavage by CASP3.
    • 细胞定位Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 4933407H12Rik antibody
      • A type potassium channel modulatory protein 3 antibody
      • A-type potassium channel modulatory protein 3 antibody
      • AI413860 antibody
      • Calsenilin antibody
      • CSEN antibody
      • CSEN_HUMAN antibody
      • DRE antagonist modulator antibody
      • DRE-antagonist modulator antibody
      • DREAM antibody
      • EF hand transcription factor antibody
      • KCHIP 3 antibody
      • KChIP3 antibody
      • KCNIP 3 antibody
      • Kcnip3 antibody
      • Kv channel interacting protein 3 antibody
      • Kv channel-interacting protein 3 antibody
      • MGC18289 antibody
      • Potassium channel interacting protein 3 antibody
      • R74849 antibody
      see all

    Anti-CSEN antibody (ab41717)参考文献

    ab41717 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab41717.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"