概述

  • 产品名称Anti-CSEN抗体
    参阅全部 CSEN 一抗
  • 描述
    兔多克隆抗体to CSEN
  • 特异性Detects KChIP 3 from rabbit cerebellar granule cells.
  • 经测试应用适用于: IHC-Fr, IHC-P, ICC, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Rabbit, Human, Non Human Primates
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide corresponding to Mouse CSEN aa 30-45.
    Sequence:

    IKWQRPRFTRQALMRC


    (Peptide available as ab5866)

  • 阳性对照
    • Immunohistochemical staining of KChIP3 in rabbit granule cells yields a punctate staining pattern at the plasma membrane.

性能

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应用

Our Abpromise guarantee covers the use of ab3474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/25.
IHC-P Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
    May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
  • 组织特异性Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
  • 序列相似性Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 翻译后修饰Palmitoylated. Palmitoylation enhances association with the plasma membrane.
    Proteolytically cleaved by caspase-3.
    Phosphorylation at Ser-63 inhibits cleavage by CASP3.
  • 细胞定位Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4933407H12Rik antibody
    • A type potassium channel modulatory protein 3 antibody
    • A-type potassium channel modulatory protein 3 antibody
    • AI413860 antibody
    • Calsenilin antibody
    • CSEN antibody
    • CSEN_HUMAN antibody
    • DRE antagonist modulator antibody
    • DRE-antagonist modulator antibody
    • DREAM antibody
    • EF hand transcription factor antibody
    • KCHIP 3 antibody
    • KChIP3 antibody
    • KCNIP 3 antibody
    • Kcnip3 antibody
    • Kv channel interacting protein 3 antibody
    • Kv channel-interacting protein 3 antibody
    • MGC18289 antibody
    • Potassium channel interacting protein 3 antibody
    • R74849 antibody
    see all

Anti-CSEN antibody 图像

  • Immunolocalization of CSEN in Rabbit granule cells using ab3474.

Anti-CSEN antibody (ab3474)参考文献

ab3474 has not yet been referenced specifically in any publications.

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