概述

  • 产品名称Anti-CRYBA4抗体
    参阅全部 CRYBA4 一抗
  • 描述
    兔多克隆抗体to CRYBA4
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Guinea pig, Cow, Dog, Pig, Monkey
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 1 - 150 of Human CRYBA4 (NP_001877).

  • 阳性对照
    • WB: 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lyates IF: HeLa cells

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG

相关产品

应用

Our Abpromise guarantee covers the use of ab97771 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 22 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Crystallins are the dominant structural components of the vertebrate eye lens.
  • 疾病相关Defects in CRYBA4 are the cause of cataract zonular type 2 (CZ2) [MIM:610425]; also known as lamellar cataract 2. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
    Defects in CRYBA4 are a cause of microphthalmia isolated with cataract type 4 (MCOPCT4) [MIM:610426]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
  • 序列相似性Belongs to the beta/gamma-crystallin family.
    Contains 4 beta/gamma crystallin 'Greek key' domains.
  • 结构域Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta A4 crystallin antibody
    • Beta crystallin A4 antibody
    • Beta-A4 crystallin antibody
    • Beta-crystallin A4 antibody
    • CRBA4_HUMAN antibody
    • CRYBA4 antibody
    • Crystallin beta A4 antibody
    • Crystallin, beta polypeptide A4 antibody
    • Eye lens structural protein antibody
    • MCOPCT4 antibody
    see all

Anti-CRYBA4 antibody 图像

  • All lanes : Anti-CRYBA4 antibody (ab97771) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 22 kDa
  • ab97771, at a 1/200 dilution, staining CRYBA4 in paraformaldehyde-fixed HeLa by Immunofluorescence analysis. Right image is merged with a DNA probe.

Anti-CRYBA4 antibody (ab97771)参考文献

ab97771 has not yet been referenced specifically in any publications.

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