概述

  • 产品名称Anti-CRY2抗体
    参阅全部 CRY2 一抗
  • 描述
    兔多克隆抗体to CRY2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 158-207, IELNGQKPPL TYKRFQAIIS RMELPKKPVG LVTSQQMESC RAEIQENHDE, of Human CRY2 (NP_066940, Q49AN0).

  • 阳性对照
    • U937 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab102542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 67 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK
    NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK
    NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
  • 组织特异性Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
  • 序列相似性Belongs to the DNA photolyase class-1 family.
    Contains 1 DNA photolyase domain.
  • 翻译后修饰Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
    Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation.
  • 细胞定位Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
  • Information by UniProt
  • 数据库链接
  • 别名
    • cry2 antibody
    • CRY2_HUMAN antibody
    • cryptochrome 2 (photolyase like) antibody
    • Cryptochrome 2 antibody
    • Cryptochrome-2 antibody
    • FLJ10332 antibody
    • growth inhibiting protein 37 antibody
    • HCRY2 antibody
    • KIAA0658 antibody
    • PHLL2 antibody
    • Photolyase like antibody
    see all

Anti-CRY2 antibody 图像

  • Anti-CRY2 antibody (ab102542) at 1 µg/ml + U937 cell lysate at 10 µg

    Predicted band size : 67 kDa

Anti-CRY2 antibody (ab102542)参考文献

ab102542 has not yet been referenced specifically in any publications.

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