概述

  • 产品名称Anti-CROCC抗体
    参阅全部 CROCC 一抗
  • 描述
    兔多克隆抗体to CROCC
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: LEAEKEELSE EIAALQQERD EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ SRQEQDRSTV NALTSELRDL R, corresponding to amino acids 1031-1121 of Human CROCC

  • 阳性对照
    • Human fallopian tube tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab121694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

靶标

  • 功能Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.
  • 序列相似性Belongs to the rootletin family.
  • 翻译后修饰Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm > cytoskeleton > centrosome > centriole. In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ciliary rootlet coiled coil antibody
    • Ciliary rootlet coiled-coil protein antibody
    • Crocc antibody
    • CROCC_HUMAN antibody
    • KIAA0445 antibody
    • Rootletin antibody
    see all

Anti-CROCC antibody 图像

  • Immunohistochemical staining of paraffin embedded Human fallopian tube tissue, using 1/4000 ab121694.

Anti-CROCC antibody (ab121694)参考文献

ab121694 has not yet been referenced specifically in any publications.

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